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![]() ![]() 1, 2 The purpose of this article is to summarize the characteristics of the database used for the latest revision to describe the most important findings from the multiple analyses performed leading to the recommendations for changes introduced in the eighth edition to comment on those situations beyond the official T, N, and M descriptors that need rules for homogenous classification and to point out the clinical and research implications of the new classification. This has meant the consolidation of a data-based process for the periodic revision of the classification, which started in the early 2000s with the revision of the sixth edition toward the seventh edition. The revisions introduced in the eighth edition of the tumor, node, and metastasis (TNM) classification of lung cancer have emanated from analyses of the International Association for the Study of Lung Cancer (IASLC) database. ![]() ![]() Different categories are created for single and multiple extrathoracic metastases.Quantification of nodal disease has prognostic impact.More subgroups are created based on tumor size.Practical Implications for Continuing Education This revision enhances our capacity for prognostication and will have an important impact in the management of patients with lung cancer and in future research. Stage IA is now divided into IA1, IA2, and IA3 to accommodate T1a, T1b, and T1cN0M0 tumors, respectively all N1 disease is stage IIB except for T3-T4N1M0 tumors, which are stage IIIA a new stage IIIC is created for T3-T4N3M0 tumors and stage IV is divided into IVA (M1a and M1b) and IVB (M1c). For the metastasis (M) component, M1a (intrathoracic metastases) remains unchanged, but extrathoracic metastases are divided into a single extrathoracic metastasis (new M1b) and multiple extrathoracic metastases in a single organ or multiple organs (M1c). The lymph node (N) component descriptors are unchanged, but the number of involved nodal stations has prognostic impact. Visceral pleural invasion remains unchanged, and mediastinal pleura invasion, which is seldom used, disappears as a T descriptor. ![]() Total atelectasis/pneumonitis was classified as a T2 descriptor, because it has a T2 prognosis. Endobronchial tumors located <2 cm from the carina have better prognosis than those with any other T3 descriptor and were classified as T2. Tis and T1mi were introduced for adenocarcinoma in situ and minimally invasive adenocarcinoma, respectively. Among tumor (T) descriptors, the following new tumor-size groups were created: T1a, ≤1 cm T1b, >1 to 2 cm T1c, >2 to 3 cm T2a, >3 to 4 cm T2b, >4 to 5 cm T3, >5 to 7 cm and T4, >7 cm. The revision for the eighth edition of the tumor, node, and metastasis (TNM) classification of lung cancer was based on analyses of the International Association for the Study of Lung Cancer database, which included 77,156 evaluable patients diagnosed with lung cancer from 1999 to 2010. ![]() ![]() ![]() ![]() Or take a name that has otherwise negative connotations, like Anakin (Darth Vader), and raise a sweet kiddo that’ll turn the name on its head. That doesn’t mean they’re off-limits, though! Choose a name rooted in fantasy and give it to a strong female character to seal the deal for your own headstrong girl named Hermione. Some of the best names have already been taken by amazing authors and lovely characters. 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Obviously, the name doesn’t make the kid, and they’ll embark upon their own journey, but it’s always nice to give them a magical start. But now is your chance to give your kid the name no one else has. You probably didn’t know a bunch of people named Daenerys growing up. Lord of the Rings, The Chronicles of Narnia, Harry Potter, or Game of Thrones are only a few worlds filled with amazing names. If there’s one genre you can count on for unique and fantastic names, it’s fantasy. There are so many name options - good and bad. Regardless, whether you’re looking to name your next precious babe or the lead protagonist in your next novel, the name struggle can be hard… and fun. Or perhaps you enjoy creating fantastically unique characters to play or write about. Maybe you’re simply into otherworldly games and fantasy fiction. ![]() Feeling like your head is in the clouds? Like you’re dreaming up a fantasy? 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